GRADUATES GET CREATIVE ABOUT JOINING THE DAILY BUMP ’N’ GRIND

first_img Tags: NULL Show Comments ▼ KCS-content whatsapp GRADUATES GET CREATIVE ABOUT JOINING THE DAILY BUMP ’N’ GRIND Share IT SEEMS the yoof of today is becoming ever more resourceful when it comes to securing a first job, despite all the sympathetic noises from older generations over the plight of school-leavers and graduates.One enterprising young chap, about to head into his final year studying economics at Nottingham, wants to use the money he would have spent on a masters in finance to pay a City firm to hire him for a year.Vishal Sharma, who already has an internship in corporate finance at Deloitte under his belt, tells me he’s looking to pay out for a junior analyst position at an investment bank, prop shop or hedge fund – and that it’ll be a “better investment” than stumping up for a costly further education course.An unusual proposition, that – though it’s nothing compared to the lengths his peers are going to over the pond in the US. One “young ambitious MBA female student” has even put up a classified ad on the Casual Encounters section of Craigslist – the place for postings dedicated to casual sex – with a view to exchanging her body for the benefits of a fat contact book.“This is a serious posting – I am not looking for résumé reviews or just interviews – have done a lot of those before,” says our negotiating vixen. “And we will not proceed to anything until you find me a job…”Times are clearly even harder than we thought.HORSING AROUNDSquare Milers who have honed their skills on horseback in line with the recent explosion in the popularity of polo should watch out.The Hurlingham Polo Association – the sport’s regulator – is introducing the widespread use of breathalysers to prevent players coming onto the pitch under the influence of alcohol.All very sensible, I’m sure – though players are indignant. “It’s very rare for us to go out there having had a drink at lunch,” one amateur enthusiast from the City tells me. “We leave the boozing to the spectators…”The Capitalist will certainly toast to that.HELL OR HIGH WATERCity sailors already feeling the twinges of nostalgia after Cowes Week earlier this month should be cheered by the news that there’s another nautical outing in the offing.Who else to lead the way but Mike Slade, the chief executive of property group Helical Bar, who’ll be out on the water yet again later today aboard his Icap Leopard yacht, aiming to break the record for the Sevenstar Round Britain and Ireland Race in under seven days, four hours, 29 minutes and 40 seconds. This time, though, there’ll be the chance for landlubbers to compete in the race too, since there’ll be a virtual competition going on at the same time on the Leopard’s website, www.leopard3.com. Perhaps Slade’s employees back at base could use the opportunity to score some points against their seafaring boss in absentia? by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailNoteabley25 Funny Notes Written By StrangersNoteableyZen HeraldThe Truth About Why ’40s Actor John Wayne Didn’t Serve In WWII Has Come To LightZen HeraldBetterBe20 Stunning Female AthletesBetterBeautooverload.comDeclassified Vietnam War Photos The Public Wasn’t Meant To Seeautooverload.comAtlantic MirrorA Kilimanjaro Discovery Has Proved This About The BibleAtlantic MirrorTotal PastThe Ingenious Reason There Are No Mosquitoes At Disney WorldTotal PastElite HeraldKate Middleton Dropped An Unexpected Baby BombshellElite HeraldTrading BlvdThis Picture of Prince Harry & Father at The Same Age Will Shock YouTrading Blvd whatsapp Sunday 22 August 2010 9:34 pmlast_img read more

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Ireland squad for summer Tests 2021

first_imgAndy Farrell has selected 37 players for the matches against Japan and the USA Jacob Stockdale (Ulster)ForwardsRyan Baird (Leinster)Finlay Bealham (Connacht)Paul Boyle (Connacht)Ed Byrne (Leinster)Gavin Coombes (Munster)Ultan Dillane (Connacht)Peter Dooley (Leinster)Caelan Doris (Leinster)Dave Heffernan (Connacht)Rob Herring (Ulster)Ronan Kelleher (Leinster)Dave Kilcoyne (Munster)Ross Molony (Leinster)Peter O’Mahony (Munster)Tom O’Toole (Ulster)James Ryan (Leinster)John Ryan (Munster)Nick Timoney (Ulster)Josh van der Flier (Leinster)Fineen Wycherley (Munster) Can’t get to the shops? You can download the digital edition of Rugby World straight to your tablet or subscribe to the print edition to get the magazine delivered to your door.Follow Rugby World on Facebook, Instagram and Twitter. LATEST RUGBY WORLD MAGAZINE SUBSCRIPTION DEALScenter_img Garry Ringrose takes on Japan at RWC 2019 (Sportsfile/Getty Images) Ireland squad for summer Tests 2021Andy Farrell has named a 37-man Ireland squad for their Tests against Japan and the USA next month.There are 11 uncapped players included – Ulster’s Robert Baloucoune, Tom O’Toole and Nick Timoney, Caolin Blade, Tom Daly and Paul Boyle of Connacht, Leinster’s Harry Byrne, Peter Dooley and Ross Molony, and Gavin Coombes and Fineen Wycherley of Munster.Experienced internationals Johnny Sexton, Cian Healy and Keith Earls have all been rested for the summer Tests, while Joey Carbery is set to make his first Test appearance since the 2019 Rugby World Cup.The squad will come together on Tuesday 22 June ahead of the two matches at the Aviva Stadium against Japan (1pm, 3 July) and the USA (7.15pm, 10 July). Both Tests will be broadcast live on RTE and Channel 4.Ireland head coach Andy Farrell said: “I know the players will come in eager to make the most of this opportunity to pull on the green jersey and play in front of supporters at the Aviva Stadium for the first time in 18 months.“Johnny (Sexton), Cian (Healy) and Keith (Earls) will not be involved in this window as we grow the experience of other players.”Ireland squad for summer Tests 2021BacksWill Addison (Ulster)Robert Baloucoune (Ulster)Caolin Blade (Connacht)Billy Burns (Ulster)Harry Byrne (Leinster)Joey Carbery (Munster)Craig Casey (Munster)Andrew Conway (Munster)Shane Daly (Munster)Tom Daly (Connacht)Chris Farrell (Munster)Jamison Gibson Park (Leinster)Hugo Keenan (Leinster)Jordan Larmour (Leinster)Stuart McCloskey (Ulster)Garry Ringrose (Leinster) – Replaced by James Hume (Ulster) on 16 June due to a shoulder issuelast_img read more

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Friday Funnies – Possibly the best scrum celebration ever

first_imgFriday Dec 14, 2012 Friday Funnies – Possibly the best scrum celebration ever While the flashy backs make headlines with hat-tricks, outrageous celebrations, and big dives over the tryline, it’s the guys up front that often do the grunt work that allows those opportunities. Here’s a quick look at a great moment from a few weeks back. Being a prop isn’t exactly glamourous, and although it could be argued that at times scrumming isn’t quite what it used to be, it’s an important aspect of rugby that tends to be overlooked.So when London Wasps prop Phil Swainston celebrated winning a scrum penalty vs Leicester Tigers as though he had scored a try, it caught the attention and made for a great piece of footage.“We worked really hard all week on the scrum and it’s something we really put a lot of focus on and to get a reward out of that, and even though it’s not a full strength Leicester, it’s still a real postive and you’ve got to celebrate when you get these wins,” Swainston said post match.“People say you don’t feel the pressure, but you feel the pressure on those scrums, and you’re just trying not to go down because you don’t know where the penalties going to go.”Showing he’s a gent, he also acknowledged the good work by the backs. “The backs really kicked well and gave us possesion, so that’s all you can really ask for,” he added.Time: 0:34Credit: LondonWaspsOfficialFollow @RugbydumpADVERTISEMENT Posted By: rugbydump Share Send Thanks Sorry there has been an error Funnies , See it to Believe it Related Articles 29 WEEKS AGO WATCH: American reacts to brilliant Nigel… 29 WEEKS AGO Video of John Kirwan apologising while wearing… 29 WEEKS AGO Simon Zebo reveals how ‘absolute lunatic’… From the WebThis Video Will Soon Be Banned. Watch Before It’s DeletedSecrets RevealedUrologists Stunned: Forget the Blue Pill, This “Fixes” Your EDSmart Life ReportsYou Won’t Believe What the World’s Most Beautiful Girl Looks Like TodayNueeyDoctors Stunned: She Removes Her Wrinkles With This Inexpensive TipSmart Life ReportsIf You Have Ringing Ears Do This Immediately (Ends Tinnitus)Healthier Living10 Types of Women You Should Never MarryNueeyThe content you see here is paid for by the advertiser or content provider whose link you click on, and is recommended to you by Revcontent. As the leading platform for native advertising and content recommendation, Revcontent uses interest based targeting to select content that we think will be of particular interest to you. We encourage you to view your opt out options in Revcontent’s Privacy PolicyWant your content to appear on sites like this?Increase Your Engagement Now!Want to report this publisher’s content as misinformation?Submit a ReportGot it, thanks!Remove Content Link?Please choose a reason below:Fake NewsMisleadingNot InterestedOffensiveRepetitiveSubmitCancellast_img read more

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W(an)W(an)S(hu) House / reMIX studio

first_imgArchDaily China Gallery Area:  1100 m² Year Completion year of this architecture project W(an)W(an)S(hu) House / reMIX studio ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/931601/w-an-w-an-s-hu-remix-studio Clipboard “COPY” Architects: reMIX studio Area Area of this architecture project Photographs:  Federico RubertoSave this picture!South volume’s terrace and connection to the top level. Image © Federico RubertoRecommended ProductsPaintLunawoodThermowood – Premium Surface FinishingMetallicsSculptformClick-on Battens in Ivanhoe ApartmentsWindowsKalwall®Facades – Window ReplacementsWindowspanoramah!®ah!38 – FlexibilityText description provided by the architects. The project is an extension designed to host private residential spaces as well as spaces for a local artists community. The intervention connects and mediates the presence of two existing volumes; it grows around the two separated units generating different light conditions, fusing in a non-linear sequence the existing programs and the “new”, which comprises of creative disciplines such as sculpting, painting, pottery. The volumes weave around in their bare materiality enveloping more private and secluded spaces, interiors that are of three types: meditation, rest and discussion.Save this picture!South volume’s yoga terrace. Image © Federico RubertoThe volumes overground are defined by layers that, keeping a calculated balance between dissolution and solidification, work mainly on one function: mediating and organizing through few formal gestures the “incalculable”: light. The composition, texture and density of the facades result from the interpolation of three parameters: degree of reflection/refraction of direct light (artistic requirements, maximization of view from interior to exterior (living requirements, and minimization of visual permeability from exterior to interior (privacy.Save this picture!Models, first (wood) and second option (Perspex)Save this picture!Top view and elevationSave this picture!Presentation modelMaterials are kept to the bare minimum; anodized aluminum envelops all the new overground terraces and glass volumes, whilst rough concrete defines the underground spaces. The program has no identifiable divisions, no internal boundaries define the newly inserted activities, which are diluted by light and transformed into programmatic gradients. For this reason each space (spatial sequence is surrounded by a continuous system, a porous envelope made by glass and several layers of a differently oriented mesh —superimposed sheets that have apertures and densities varying according to specific requirements.Save this picture!South volume’s yoga terrace and projection room. Image © Federico RubertoSave this picture!Exterior ramps of the South terraces. Image © Federico RubertoThis operation generates different degrees of visual permeability, reflection and ultimately privacy. The new addition appears solid in volume/color/texture if looked from the outside, but it visually vanishes when “lived” from the inside, an effect generated by the juxtaposition of differently oriented layers of stretched aluminum mesh that “opening up” or “closing down” force the eyes to see trough or not, to catch peculiar reflections according to where they are placed.Save this picture!North volume’s materials. Image © Federico RubertoThe landscape around the building [unfinished at this stage] is supposed to work formally in continuity with the architectural mass, establishing ground links between the two poles of the plot. The material simplicity of the hardscape -wooden deck and aluminum mesh, works in conjunction with a less formally determined softscape which has set plants and groups of essences placed emphasizing the presence of water, the amount of solar irradiation, and the desired degree of privacy from the surroundings.Save this picture!View from the South volume seen from the elevated terrace of the North volume. Image © Federico RubertoAt the moment there is no effective presence of vegetation on the elevated terraces and on the facades, this is because time has not yet run its course. By the end of summer we expect to be able to catch layers of vegetation expanding all around the building, growing from the elevated terraces that have embedded soil containers along their perimeters, and from the base of each metallic surface. It is only a matter of time, and of weather, for the rough geometric definition of the envelope to loose itself up whilst being parasitized by the green. Bringing such unpredictable element to fuse with the linear austerity of the intervention (to be an added layer composing the facade will not only build more interesting aesthetic effects but will help maintaining the interior cooler in the hot days of summer.Save this picture!The two extension viewed from the West side. Image © Federico RubertoProject gallerySee allShow lessVAN ROU / AML Design StudioSelected ProjectsModel Infill House / Ben Koush AssociatesSelected Projects Share Photographs “COPY” ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/931601/w-an-w-an-s-hu-remix-studio Clipboard CopyGallery, Houses, Renovation•Beijing, China Save this picture!From the North painting room towards the South block. Image © Federico Ruberto+ 28Curated by 韩爽 – HAN Shuang Share Year:  Projects 2018 W(an)W(an)S(hu) House / reMIX studioSave this projectSaveW(an)W(an)S(hu) House / reMIX studio CopyAbout this officereMIX studioOfficeFollowProductsGlassSteel#TagsProjectsBuilt ProjectsSelected ProjectsCultural ArchitectureMuseums & ExhibitGalleryResidential ArchitectureHousesRefurbishmentRenovationBeijingOn FacebookChinaPublished on January 24, 2020Cite: “W(an)W(an)S(hu) House / reMIX studio ” 23 Jan 2020. ArchDaily. Accessed 10 Jun 2021. ISSN 0719-8884Browse the CatalogPanels / Prefabricated AssembliesTechnowoodSiding Façade SystemWindowsMitrexSolar WindowMetal PanelsAurubisPatinated Copper: Nordic Green/Blue/Turquoise/SpecialMetal PanelsDri-DesignMetal Panels – CopperIn architectureSikaBuilding Envelope SystemsExterior DeckingLunawoodThermowood DeckingMembranesEffisusFaçade Protection – Breather+Metal PanelsPure + FreeFormCustom Metal Cladding – Legacy Fund 1 BuildingWood Boards / HPL PanelsInvestwoodWood Fiber Partition Walls – ValchromatDoorsLinvisibileLinvisibile FILO 10 Vertical Pivot Door | BrezzaSkylightsFAKROEnergy-efficient roof window FTT ThermoToilets / BidetsBritexToilets – Accessible Centurion PanMore products »Save想阅读文章的中文版本吗?WWS艺术社区 / 临界工作室是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! 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Days after gasoline attack, TV station owner told to leave town under pain of death

first_imgNews Organisation RSF_en May 13, 2021 Find out more April 27, 2021 Find out more ColombiaAmericas to go further 2011-2020: A study of journalist murders in Latin America confirms the importance of strengthening protection policies News RSF begins research into mechanisms for protecting journalists in Latin America Mario Estebán López, the owner and director of regional TV station Canal 22 RAV Televisión, could be executed if he does not leave the city of Ipiales, in the southwestern department of Nariño, by tomorrow, according to a warning he received on the night of 8 June, nine days after he was nearly killed by three unidentified attackers armed with gasoline.In the attack with gasoline, which took place on 31 May, he was ambushed in his car near his home and came close to being strangled and burned alive.“I thought they were kidnapping me,” he told Reporters Without Borders. “I smelled gasoline, I felt the pressure of the flex around neck (…) Then a man in car approached and told (his accomplices) that there were police nearby. I was left in the middle of the road soaked in gasoline. All this lasted an hour and a half.”López, 28, has been under permanent threat even since he started covering sensitive local stories. He was given his first warning after a report after actions by a neighbourhood’s residents against drug dealers without any reaction from the local authorities.He received another threat, this time from the municipal authorities, after a report that reflected badly on both the municipal government and the local police. Nariño is known for its law and order problems.The mayor of Ipiales brought a defamation suit against him on 5 June, alleging that López had accused him of instigating the 31 May attack with gasoline. López has denied blaming the attack on the mayor.“I feel persecuted,” he told Reporters Without Borders. “I have had to postpone my wedding. Certain colleagues, journalists who support the municipal government, are against me and say I am hurting the city’s image. I want to put pressure on the government to provide me with protection so that I can continue working.”“The Ipiales police should provide López with protection without awaiting the results of the investigation into the threats against him,” Reporters Without Borders said. “Instead of suing him, why didn’t the municipal government come to his help immediately after the 31 May attack? And why didn’t the mayor accept López’s offer to come and defend himself on López’s TV station?”Colombia is a dangerous country for journalists and continues to endure a civil war in which justice has never been rendered for its crimes. Reporters Without Borders points out that Impunity, a major documentary on Colombia’s paramilitaries by the filmmaker Juan Lozano and the journalist Hollman Morris, is to be screened at 5 p.m. on 20 June at Bogotá’s Teatro México. This is a preview with English subtitles:center_img October 21, 2020 Find out more Receive email alerts Help by sharing this information ColombiaAmericas RSF, IFEX-ALC and Media Defence, support FLIP and journalist Diana Díaz against state harassment in Colombia Reports Follow the news on Colombia June 10, 2011 – Updated on January 20, 2016 Days after gasoline attack, TV station owner told to leave town under pain of death Newslast_img read more

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New Biomarker Analyses from Patritumab Deruxtecan Phase 1 Study in Patients with EGFR-Mutated NSCLC…

first_img Twitter New Biomarker Analyses from Patritumab Deruxtecan Phase 1 Study in Patients with EGFR-Mutated NSCLC Presented at WCLC 2020 TAGS  MUNICH & BASKING RIDGE, N.J.–(BUSINESS WIRE)–Jan 29, 2021– Exploratory biomarker analyses from an ongoing phase 1 study of Daiichi Sankyo Company, Limited’s (hereafter, Daiichi Sankyo) patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate (ADC), in patients with previously treated EGFR-mutated metastatic/unresectable non-small cell lung cancer (NSCLC) were highlighted in a poster presentation today at the IASLC 2020 World Conference on Lung Cancer (WCLC), hosted by the International Association for the Study of Lung Cancer. Lung cancer is the leading cause of cancer death among both men and women, and accounts for about one-fifth of all cancer deaths globally, with 80 to 85 percent classified as NSCLC. 1,2 For patients with metastatic disease, prognosis is particularly poor, as only 6 to 10 percent live beyond five years after diagnosis. 3 Approximately 25 to 30 percent of lung cancers worldwide have an EGFR-activating mutation, and it is estimated that about 83 percent of all NSCLC tumors express the HER3 protein, which can be associated with an increased incidence of metastases, reduced survival and resistance to standard treatment. 4,5,6 There currently are no HER3 directed therapies approved for the treatment of NSCLC. The exploratory analyses assessed genomic alterations in 56 evaluable patients with EGFR inhibitor resistant NSCLC receiving patritumab deruxtecan in the dose escalation (n=12) and cohort 1 of the dose expansion (n=45) part of the phase 1 study. HER3 expression was evaluated by H score, which is a method of assessing the percentage of tumor cells with cell membrane staining. Nearly all evaluable tumors expressed high levels of HER3 at baseline, with a median membrane H score of 180 (range: 2-280). Preliminary assessments suggested that there was a trend toward higher HER3 membrane expression at baseline in patients who obtained a confirmed response to treatment with patritumab deruxtecan. Analysis is ongoing with specimens from additional patients in the study. Diverse genomic alterations comprising known EGFR tyrosine kinase inhibitor (TKI) resistance mechanisms were present in pretreatment tumor tissues and circulating tumor DNA (ctDNA), including EGFR T790M mutation (53 percent); MET amplification (8 percent); multiple oncogenic fusions involving FGFR3, NTRK1, BRAF, ALK, RET or ROS1 (8 percent); and HER2 mutation (4 percent). Clinical responses were observed in patients with diverse mechanisms of EGFR TKI resistance, including mechanisms not directly related to EGFR. Patients with evaluable ctDNA at pre- and post-treatment showed reduction of EGFR activation mutations, and primary analysis suggests that the majority of patients with confirmed clinical response were more likely to have ctDNA clearance of EGFR-activating mutations at week 3 or week 6. Absence of ctDNA clearance of EGFR-activating mutations was associated with a best overall response of progressive disease. “These data provide important insights about how a HER3 directed therapy may interact in previously treated NSCLC tumors with diverse mechanisms of EGFR TKI resistance, including mechanisms not directly related to EGFR,” said Pasi A. Jänne, MD, PhD, Director, Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute. “While an association between higher levels of HER3 expression and clinical activity was seen with patritumab deruxtecan, additional analyses from this study and additional studies are needed to better understand the role of HER3 expression alone in the optimal selection of patients.” “Translational research such as this is essential to advancing targeted therapy for patients with NSCLC with disease progression following standard treatments,” said Gilles Gallant, BPharm, PhD, FOPQ, Senior Vice President, Global Head, Oncology Development, Oncology R&D, Daiichi Sankyo. “In patients with NSCLC and other tumor types that overexpress HER3, we will continue our exploration of potential biomarkers for patient selection and tumor response in our ongoing clinical development of patritumab deruxtecan.” About the Phase 1 NSCLC Study The global, multicenter, open label, two-part phase 1 study is evaluating patritumab deruxtecan in previously treated patients with metastatic or unresectable NSCLC. The dose escalation part of the study evaluated patients with EGFR-mutated disease either with progression on osimertinib or T790M-negative after progression on erlotinib, gefitinib or afatinib. The primary objective of this part of the study was to assess the safety and tolerability of patritumab deruxtecan and determine the recommended dose for expansion (RDE). The dose expansion part of the study is evaluating patritumab deruxtecan at the RDE (5.6 mg/kg every three weeks) in three cohorts. Cohort 1 includes patients with metastatic or unresectable EGFR-mutated NSCLC who experienced disease progression after taking one or more EGFR TKIs and one or more platinum based chemotherapy regimens. Cohort 2 includes patients with squamous or non-squamous NSCLC without EGFR-activating mutations, following platinum-based chemotherapy and following an anti-PD-1 or anti-PD-L1 antibody regimen. Cohort 3 includes patients with NSCLC with EGFR-activating mutations including any histology other than combined small cell and non-small cell lung cancer; patients in Cohort 3 will be randomized 1:1 to receive the RDE regimen (Cohort 3a) or an escalating up-titration regimen of patritumab deruxtecan (Cohort 3b). Preliminary data from the dose escalation part of the study were presented previously at the 2019 World Conference on Lung Cancer, and early data from the dose escalation part (5.6 mg/kg dose) and Cohort 1 of the dose expansion were presented at the 2020 European Society of Medical Oncology (ESMO) Virtual Congress. The primary objective of the dose expansion part of the study is to assess efficacy of patritumab deruxtecan as measured by confirmed objective response rate (ORR) assessed by blinded independent central review. Secondary study endpoints include investigator-assessed ORR; safety, tolerability and preliminary efficacy; and characterization of the pharmacokinetics of patritumab deruxtecan. The study is currently enrolling patients at multiple sites in the U.S., Europe, Japan and other countries in Asia. For more information, visit ClinicalTrials.gov. About Non-Small Cell Lung Cancer Lung cancer is the most common cancer and the leading cause of cancer mortality worldwide; there were an estimated 2.2 million new cases of lung cancer and 1.8 million deaths in 2020. 1 Most lung cancers are diagnosed at an advanced or metastatic stage. 2 Non-small cell lung cancer (NSCLC) accounts for 80 to 85 percent of all lung cancers. 7 The introduction of targeted therapies and checkpoint inhibitors in the past decade has improved the treatment landscape for patients with advanced or metastatic NSCLC; however, the prognosis is particularly poor among patients who have progressed after treatment with standard therapies. For those who are not eligible for current treatments, or whose cancer continues to progress, new therapeutic approaches are needed. 8 The mutationally-activated EGFR tyrosine kinase is a well-established oncogenic driver and molecular target for management of advanced stage NSCLC. 9 For patients with advanced EGFR-mutated NSCLC, targeted therapy with EGFR TKIs offer higher response rates and progression-free survival compared to chemotherapy. 8 However, most patients eventually develop resistance to these therapies, and standard treatment options are limited. 10 Clinical resistance to EGFR TKIs has been linked to multiple molecular mechanisms, and in many cases, the underlying mechanism of resistance remains unknown. 11,12,13 About HER3 HER3 is a member of the EGFR family of receptor tyrosine kinases, which are associated with aberrant cell proliferation and survival. 14 Approximately 25 to 30 percent of lung cancers worldwide have an EGFR-activating mutation, and it is estimated that about 83 percent of tumors express the HER3 protein, which can be associated with an increased incidence of metastases, reduced survival and resistance to standard of care treatment. 4,5,6 Currently, no HER3 directed medicines are approved for the treatment of cancer. About Patritumab Deruxtecan Patritumab deruxtecan (HER3-DXd; U3-1402) is one of three lead DXd antibody drug conjugates (ADC) in the oncology pipeline of Daiichi Sankyo. Designed using Daiichi Sankyo’s proprietary DXd ADC technology, patritumab deruxtecan is comprised of a human anti-HER3 antibody attached to a topoisomerase I inhibitor payload, an exatecan derivative, via a stable tetrapeptide-based cleavable linker. Patritumab deruxtecan is currently being evaluated in a comprehensive development program across multiple cancers as both a monotherapy and in combination with other anticancer treatments. The development program includes a phase 2 study in patients with advanced/metastatic colorectal cancer with progression following at least two prior lines of systemic therapy; a phase 1/2 study in HER3 expressing metastatic breast cancer; a phase 1 study in combination with osimertinib in locally advanced/metastatic EGFR-mutated NSCLS; and, a phase 1 study in previously treated patients with metastatic or unresectable NSCLC. Patritumab deruxtecan is an investigational agent that has not been approved for any indication in any country. Safety and efficacy have not been established. About Daiichi Sankyo Cancer Enterprise The mission of Daiichi Sankyo Cancer Enterprise is to leverage our world-class, innovative science and push beyond traditional thinking to create meaningful treatments for patients with cancer. We are dedicated to transforming science into value for patients, and this sense of obligation informs everything we do. Anchored by our DXd antibody drug conjugate (ADC) technology, our powerful research engines include biologics, medicinal chemistry, modality and other research laboratories in Japan, and Plexxikon Inc., our small molecule structure-guided R&D center in Berkeley, CA. For more information, please visit: www.DSCancerEnterprise.com. About Daiichi Sankyo Daiichi Sankyo Group is dedicated to the creation and supply of innovative pharmaceutical therapies to improve standards of care and address diversified, unmet medical needs of people globally by leveraging our world-class science and technology. With more than 100 years of scientific expertise and a presence in more than 20 countries, Daiichi Sankyo and its 15,000 employees around the world draw upon a rich legacy of innovation and a robust pipeline of promising new medicines to help people. In addition to a strong portfolio of medicines for cardiovascular diseases, under the Group’s 2025 Vision to become a “Global Pharma Innovator with Competitive Advantage in Oncology,” Daiichi Sankyo is primarily focused on providing novel therapies in oncology, as well as other research areas centered around rare diseases and immune disorders. For more information, please visit: www.daiichisankyo.com. ————————————————————————————— References: 1 World Health Organization. GLOBOCAN 2020. Lung Cancer Fact Sheet. January 2021. 2 American Cancer Society. About Lung Cancer. Types of Lung Cancer. January 2020. 3 Goldstraw P, et al. J Thorac Oncol. 2016; 11(1):39–51. 4 Zhang YL, et al. Oncotarget. Vol. 7 No 49. 78985-78993. 5 Muller-Tidow C, et al. Cancer Res. 2005;65:1778-1772. 6 Scharpenseel, et al. Scientific Reports. 2019;9:7406. 7 American Cancer Society. Types of Non-Small Cell Lung Cancer. 2019. 8 Economopoulou P, et al. Ann Transl Med. 2018;6(8):138. 9 Planchard D, et al. Ann Oncol. 2018;29(4):iv192–237. Updated Sept. 2019. 10 Morgillo F, et al. ESMO Open. 2016;1:e000060. 11 Wu, et al. Mol Cancer. 2018;17:38. 12 Papadimitrakopoulou, et al. Ann Oncol. 2018;29(8). 13 Remon J, et al. Ann Oncol. 2018;29(1):i20–i27. 14 Mishra R, et al. Oncol Rev. 2018;12:355. View source version on businesswire.com:https://www.businesswire.com/news/home/20210129005081/en/ CONTACT: Media Contacts:Global//US: Jennifer Brennan Daiichi Sankyo, Inc. [email protected] +1 908 992 6631 (office) +1 908 900 3183 (mobile)EU: Lydia Worms Daiichi Sankyo Europe GmbH [email protected] +49 (89) 7808751 (office) +49 176 11780861 (mobile)Japan: Masashi Kawase Daiichi Sankyo Co., Ltd. [email protected] +81 3 6225 1126 (office)Investor Relations Contact: [email protected] KEYWORD: UNITED STATES JAPAN NORTH AMERICA ASIA PACIFIC EUROPE GERMANY NEW JERSEY INDUSTRY KEYWORD: PHARMACEUTICAL HEALTH ONCOLOGY CLINICAL TRIALS SOURCE: Daiichi Sankyo Copyright Business Wire 2021. PUB: 01/29/2021 08:00 AM/DISC: 01/29/2021 08:01 AM http://www.businesswire.com/news/home/20210129005081/en Twitter WhatsApp Pinterest By Digital AIM Web Support – January 29, 2021 center_img Local NewsBusiness Pinterest Facebook Facebook WhatsApp Previous articlePuma Biotechnology Presents Interim Results from the Phase II SUMMIT Trial of Neratinib for EGFR Exon 18-Mutated, Metastatic Non-Small Cell Lung Cancer at WCLC 2020Next articleWorldwide Major Mobile Phone Vendor Performance, 4Q 2020 – Smartphone Shipment Volume is Estimated to Reach 1.35 Billion Units in 2021, Up 9.1% Y-o-Y – ResearchAndMarkets.com Digital AIM Web Supportlast_img read more

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Mom takes inspiration from ‘Three Billboards’ to help find her daughter’s killer

first_imgCourtesy Kim Merryman(OKLAHOMA CITY) — A grieving mother on screen in the movie “Three Billboards Outside of Ebbing, Missouri” inspired a grieving mother off-screen.Kim Merryman took cues from Frances McDormand’s character in the Oscar-nominated film and raised money for a billboard to highlight the ongoing search for her daughter’s killer.Merryman’s daughter Emily Morgan was found shot dead alongside her best friend Totinikia “Ty” Elix in August 2016.In an effort to keep her daughter’s case in the spotlight and in hopes of “getting under the skin of the murderer,” Merryman paid for a billboard to be erected just miles from where they were found shot dead in her car.The billboard includes the victims’ names and pictures, and warns that “there is a ruthless killer in your community!”But there’s another reason Merryman chose that location.“I believe that the person responsible for the murders … lives in McAlester,” Merryman told ABC News.Steve Tanner, the assistant special agent in charge at the Oklahoma State Bureau of Investigations, told ABC News that there have not been any arrests in the case. The OSBI has an agent assigned to the case and is offering a $5,000 reward for information.The murdersMorgan, 23, and Elix, 24, were found with apparent gunshot wounds in a car on the afternoon of Aug. 26, 2016.OSBI called Merryman that evening with news that her daughter had been found dead.Merryman said that Morgan always called after dropping off her son Payden at school, and when Merryman didn’t get a call that morning, she knew something was wrong.“As the day went on and [calls to Morgan’s cellphone] kept going to voicemail, I knew. I knew in the pit of my stomach that something was very wrong,” said Merryman, who now lives with her grandson.Her inspirationMore than a year later, she saw the movie about a grieving mother whose daughter is murdered, and it resonated with her.“I didn’t go to the movies and watch it because I didn’t know how emotional it would make me and so I waited and watched it at home and it had a huge impact on me,” she said of “Three Billboards Outside of Ebbing, Missouri.”While there is only one billboard so far, Merryman is continuing to raise funds and has plans to arrange for another nearby billboard on the side of a building. She also wants to wrap a van in similar posters, for a total of three “billboards.”Merryman said that she saw the billboard for the first time yesterday, and it was “very hard.”“It was pretty emotional, very bittersweet,” she said.“I felt empowered by doing it. It’s also really sad to see them up there,” she said of Morgan and Elix.Copyright © 2018, ABC Radio. All rights reserved.last_img read more

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Flood of employment law causes confusion

first_imgFlood of employment law causes confusionOn 11 May 2004 in Personnel Today Related posts:No related photos. The Government obsession with employee rights and the subsequent flood oflegislation is now taking its toll. HR is understandably critical of the Government’s complex employment laws andthe straitjacket they find themselves in. But the profession ought to acceptsome responsibility for this – after all, the HR community did have a say inthe consultation process in the early days of drafting this legislation. Legions of employment lawyers and a wealth of resources are available asguidance, but too many employers are reluctant to change traditional workingpractices, and are making heavy weather of the new legal framework. And left to their own devices, much of British industry would struggle toconform to modern management practices, despite the weight of evidence thatit’s good for the bottom line. Participation pays off Reader interaction is vital to us at Personnel Today and last week our effortsin this area were recognised by experts looking for editorial excellence in thepublishing industry. Personneltoday.com, was awarded Interactive BusinessMagazine of the Year by the Periodical Publishers Association, beating sixother websites to this prestigious prize. Such an accolade could not have been achieved without the fantastic supportand involvement of magazine readers and users of our site. At times, we havebeen overwhelmed by your enthusiasm to participate in our surveys and competitions,write letters for publication, attend conferences, enter the Personnel TodayAwards and to have a go at our regular self test quizzes. More than 600 senior executives have joined our HR Directors Club in a bidto find business inspiration and make the most of the peer to peer networking.We suspect there are lots of other groups of readers out there who would likesimilar opportunities to meet and share experiences at live events. The levels of interactivity achieved so far reflect the dynamic nature ofthe HR community and the desire to learn and change. It also supports our viewthat delivering information to business audiences should not be a dry andpassive experience. Key to all this is a commitment to stay close to ouraudience needs and respond accordingly. So a big thank you to everyone for yourinteraction and for helping us develop this strategy. By Jane King, editor Comments are closed. Previous Article Next Articlelast_img read more

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Jackson-Stops wins prestigious London contract

first_imgHome » News » Agencies & People » Jackson-Stops wins prestigious London contract previous nextAgencies & PeopleJackson-Stops wins prestigious London contractThe Howard de Walden Estate has appointed national estate agent Jackson-Stops as one of its four retained letting agents.Sheila Manchester22nd March 201901,475 Views The Howard de Walden Estate has appointed national estate agent Jackson-Stops as one of its four retained letting agents.Over the last 12 months, Camilla Foulger and her dedicated team at Jackson-Stops’ Mayfair branch, have been working closely with The Estate and, as a result of their hard work and professional service, they have been given access to market a significant number of the Estate’s 800 residential properties.Camilla FoulgerNick Butterworth, Chief Executive of Jackson-Stops London, said, “We are extremely proud to be representing the Howard de Walden Estate. Despite not having a branch in Marylebone, our Mayfair lettings team has shown that they can apply their strong prime central London expertise to produce excellent results. This shows our agents are true experts across the wider London market, as well as in their patches, and are able to apply their years of expertise and knowledge to maximise returns for our clients.”92 acres in central LondonThe Estate’s portfolio ranges from studio apartments to mews houses, and we are looking forward to continuing to support the Estate’s strategy for enhancing this wonderful area of London.”The Howard de Walden Estate, which covers most of the buildings in 92 acres of Marylebone, central London, manages and leases properties across an area that extends from Marylebone High Street in the west, to Portland Place in the east and from Wigmore Street in the south to Marylebone Road in the north.The Estate has strong historic connections to Marylebone, which date back to 1710.The Estate valued its property portfolio at £4,427 million in 2018, and brought in £127.5 million in rental income last year. Jackson-Stops and the other three appointed agents will take a collaborative approach to marketing the properties in Marylebone.Jackson-Stops Mayfair London letting Howard de Walden Estate Nick Butterworth Camilla Foulger March 22, 2019The NegotiatorWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021last_img read more

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George H.W. Bush CSG commander visits FS Chevalier Paul

first_img View post tag: French Navy Share this article July 18, 2017 View post tag: USS Dwight D Eisenhower View post tag: US Navy Authoritiescenter_img Back to overview,Home naval-today USS George H.W. Bush CSG commander visits French frigate FS Chevalier Paul View post tag: FS Chevalier Paul The commander of the Carrier Strike Group 2 assembled around the U.S. Navy aircraft carrier USS Dwight D. Eisenhower visited French frigate FS Chevalier Paul on July 14.The visit, held on Bastille Day, promoted interoperability and U.S.-French commitment to stability in the Europe and Africa regions during operation Inherent Resolve.“Our French allies have shown warfighting credibility and commitment in our fight against ISIS,” said Rear Adm. Kenneth Whitesell. “They are an important member of our team and getting to meet their crew and see first-hand the good work they do was an invaluable experience.”While aboard the ship, Whitesell toured workspaces, reviewed the ships capabilities, met with sailors, and viewed a Bastille Day parade broadcast with the ship’s commanding officer, Capt. Hugues Laine.“Bastille Day is about freedom and presented a perfect backdrop for this visit as we and our allies work to promote freedom and prosperity in the region,” said Whitesell. “The United States and France have a long history as champions of freedom. Today is the 100th anniversary of America joining WWI on French soil, and we marched alongside our friends in the Bastille Day parade along the Champs-Elysees, reviewed by Presidents Trump and Macron. Today we celebrate both our history of independence and our commitment to a global future of freedom.” USS George H.W. Bush CSG commander visits French frigate FS Chevalier Paullast_img read more

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